Human Clinical Studies of Magnetic Duodeno-Ileostomy (MagDI)

A summary of the principal human clinical studies that have evaluated magnetic duodeno-ileostomy (MagDI) for the treatment of obesity and Type 2 Diabetes. Study details below are drawn from peer-reviewed publications; readers should consult the original articles for full methodology, sample sizes, follow-up durations, and complete results.

Written by MagnaMetabolic Editorial Team Medically reviewed by Ariel Ortiz, MD — Bariatric & Metabolic Surgery Last reviewed: June 7, 2026

First-in-Human Study

First-in-human experience of magnetic duodeno-ileostomy

Michel Gagner et al. · Obesity Surgery

First reported human experience with the MagDI System.
Demonstrated feasibility of creating a duodeno-ileal anastomosis using magnetic compression.
Reported safety profile in the initial human cohort.
Demonstrated successful anastomosis formation with magnet detachment and natural passage.

Multi-Center Early Outcomes

Multi-center early outcomes of Sleeve Plus MagDI

Surgical Endoscopy

Multi-center clinical experience combining sleeve gastrectomy with magnetic duodeno-ileostomy.
Reported early weight-loss outcomes across participating centers.
Reported early effects on Type 2 Diabetes and related metabolic markers.
Reported procedural and post-procedural safety outcomes.

Revisional Sleeve Study

MagDI after prior sleeve gastrectomy

Surgery for Obesity and Related Diseases (SOARD)

Evaluated MagDI used after a prior sleeve gastrectomy.
Patient population included weight regain after sleeve.
Patient population included insufficient weight loss after sleeve.
Patient population included recurrence of Type 2 Diabetes after sleeve.

Interpreting these studies

Currently published MagDI studies report on the first generation of human experience. Sample sizes, follow-up durations, and patient populations vary between studies and remain modest compared with long-established procedures such as sleeve gastrectomy or Roux-en-Y gastric bypass. Results from any single study should not be generalized to every patient population. Long-term outcomes beyond currently available follow-up periods are not yet established.

Scientific References

Selected primary sources informing this page. External links open in a new tab; we do not control or endorse third-party content.

Obesity SurgeryGagner M, et al. First-in-human experience of magnetic duodeno-ileostomy for the treatment of obesity and metabolic disease. Obesity Surgery.

Surgical EndoscopyMulti-center early outcomes of sleeve gastrectomy combined with magnetic duodeno-ileostomy (Sleeve Plus MagDI). Surgical Endoscopy.

SOARDMagnetic duodeno-ileal anastomosis after previous sleeve gastrectomy for weight regain, insufficient weight loss, or diabetes recurrence. Surgery for Obesity and Related Diseases (SOARD).